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It is the responsibility of those of us involved in today's biomedical research enterprise to translate the remarkable scientific innovations we are witnessing into health gains for the nation. In order to address this imperative, we at the National Institutes of Health (NIH) asked ourselves: What novel approaches can be developed that have the potential to be truly transforming for human health? To help crystallize these ideas and develop tangible strategies to advance our efforts, three years ago the NIH initiated a series of consultations with the research community to define major scientific trends collectively, with the goal of identifying thematic areas that no single NIH institute or group of institutes could tackle alone, but that the whole of the NIH needed to address. This effort led to the development of the NIH Roadmap for Medical Research, with three fundamental themes. First, we identified the need to stimulate the development of novel approaches to unravel the complexity of biologic systems and their regulation, which we encapsulated in the “New Pathways to Discovery” theme. Second, since progress is often made at the interface of preexisting disciplines, we explored ways to reduce the cultural and administrative barriers that often impede such research. To invoke an era in which scientists can cooperate in new and different ways, we drafted novel programs under the theme of “Research Teams of the Future.” One of these innovative programs is the Pioneer Award, in which the NIH provides unprecedented intellectual freedom to highly creative thinkers investigating problems of biomedical and behavioral importance. Jamaican Marriage License Records here.

Third, we heard resounding concern from basic, translational, and clinical researchers alike that their interactions were becoming more remote and difficult, that clinical research was increasingly less attractive to new investigators, and that clinician–scientists were moving away from patient-oriented research. It was clear that instigating renovations in translational and clinical science was paramount among the NIH's immediate responsibilities. This led us to formulate the third Roadmap theme, “Re-engineering the Clinical Research Enterprise.” Translational and clinical research are core components of a full-spectrum biomedical research enterprise. Yet, these critical arenas of research are hampered by increases in costs and complexity, a dearth of information systems, and increases in the regulatory burden. An explosion in clinical-service demands and reduced financial margins have sharply cut protected research time for many clinical and translational researchers and diluted the time and attention devoted to the research mission of academic institutions. The inevitable result of these changes has been, for example, difficulties in the recruitment and retention of human subjects in clinical trials and, ultimately, considerable delay in the completion of critical studies. Download Naruto Shippuden Episode 86 Subtitle Indonesia. It is more and more difficult to recruit, mentor, and retain a critical mass of clinical and translational scientists. Source Insight Crack there.